From Basic Research to the Clinic

Example 1: 

The Discovery of Losartan (an antihypertensive drug) was enabled by the fundamental research into the Renin Angiotensin Aldosterone System. 

Example 2: 

How early research by Giuseppe Brotzu into the mechanism of self-purification of the sea-water led to the discovery of Cephalosporin antibiotics. 

Example 3: 

Monoclonal Antibodies: From Discovery to Application in Breast Cancer Therapy as Herceptin. 

Example 4: 

Studying a deep Sea snail toxin led to the development of Prialt, a non-opioid drug approved by the FDA for management of severe chronic pain. 

Example 5: 

Organic chemistry research resulting in the synthesis of Biguanides led to the discovery of Metformin used for diabetes. 

Example 6: 

Early research discovering histamine, its receptors & their physiological roles (such as in allergy) led to the development of antihistamine drugs (such as Cimetidine and Diphenhydramine). 

Example 7: 

The development of rituximab, an anti-CD20 monoclonal antibody for the treatment of non-Hodgkin’s lymphomas (NHL) was enabled by the discovery of Cluster of differentiation 20 (CD20) B-lymphocyte surface molecule. 

Example 8: 

Understanding TNF- α Cytokines led to the development of Infliximab that alleviates the symptoms of Autoimmune Diseases such as rheumatoid arthritis.

Example 9: 

Understanding cholesterol metabolism led to the development of statins such as Lovastatin, which lower cholesterol levels in the body to prevent cardiovascular events.